Rams v 49ers NFL betting tips & predictions | Week 15 preview

Rams v 49ers best bets

Rams v 49ers game preview – NFL Week 15

The Los Angeles Rams head to San Francisco this Friday (AEDT) with a place at the top of the NFC West on the line in NFL Week 15.

The Rams’ wild season continued last Sunday, when they beat the high-flying Bills in a 44-42 shootout. It was an offensive showcase between the two teams, as they each scored six touchdowns, leaving the defenses helpless.

This is the third win in the last four weeks for the Rams, who are now right in contention for the division at 7-6. Quarterback Matthew Stafford combines excellently with star receivers Puka Nacua and Cooper Kupp, while running back Kyren Williams is getting the job done on the ground.

However, Los Angeles have a bottom-10 defense in terms of points conceded per game, which has been particularly exposed in the run game. As a result, it is no surprise to see them as underdogs this week at +120 with leading NFL sportsbooks.

Rams coach Sean McVay has stated that tight end Tyler Higbee is a chance to play his first game of the season this week, but there are plenty of other injury concerns. Wide Receivers Jordan Whittington and Demarcus Robinson are both battling shoulder injuries, while cornerback Cobie Durant is dealing with a chest issue.

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The 49ers have been equally inconsistent this season, failing to impress with a record of 6-7. Luckily, they are in one of the weakest divisions in the NFL, so their playoff hopes are still alive.

Last Sunday, they produced a dominant display against the Bears, winning 38-13. After keeping Chicago to just four yards on offense in the first half, it was a comfortable win, with both running back Isaac Guerrendo and wide receiver Jauan Jennings scoring twice.

This broke a run of three straight losses for San Francisco. Statistically, they rank in the top four for total offensive yards and yards allowed, but their record of 1-4 in one-score games has cost them throughout the season.

With one of the most complete rosters in the NFL, and with home-field advantage, the 49ers are favorites at -140.85 with top sports betting sites.

In a major boost, the Niners could have a pair of superstars return this week with left tackle Trent Williams (ankle) and defensive end Nick Bosa (hip) trending upwards. However, running back Isaac Guerendo is in doubt with a foot injury, while offensive tackle Ben Bartch is set for injured reserve with an ankle sprain.

Rams v 49ers NFL Thursday betting strategy

With injuries impacting the Rams offense earlier in the season, Matthew Stafford has shown how good they are at full strength over the last few weeks. The 49ers have beaten just two teams with a winning record in 2024, while they have also been consistently beaten at home. As slight underdogs in this clash, back the Rams for the upset at +120 with major online bookmakers.

Both of these teams are filled with offensive quality, so expect this clash to be full of scoring. Each of the last three 49ers games have gone over the total points line, while three of the last four Rams games have done the same. Last time these teams met, the points total comfortably cleared the over, so back this game to clear the line of 49 points at -111.11 with Marantelli Bet.

Listed as the 49ers’ WR3 heading into the season, Jauan Jennings has made the most of injuries to both Brandon Aiyuk and Deebo Samuel. He leads the team in receptions this season, earning at least seven targets in four of the last five weeks. With a high-scoring game expected, back Jennings for seven or more receptions at +225 with top NFL bookmakers.

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