NFL Week 5 betting tips, predictions & multi picks

The 2025 NFL season rolls into Week 5 with the first byes of the year, a London showcase, and two unbeaten powerhouses trying to stay perfect. The Eagles and Bills face stern tests, while Monday Night Football delivers a blockbuster as Patrick Mahomes and the Chiefs travel to Jacksonville.

From early morning action in London to a heavyweight clash in Florida to close the round, here are our best bets for every matchup, with odds from the top online bookmakers.

San Francisco 49ers v Los Angeles Rams

Friday, October 3 – 11:15am AEST – SoFi Stadium, Inglewood, CA

The 49ers enter battered and on a short turnaround, while the Rams defence has been swarming opposing quarterbacks. San Francisco have struggled to keep up when chasing games, and that’s exactly the scenario they risk here. Indoors under primetime lights, the game script points towards a tighter defensive battle than the market expects.

Minnesota Vikings v Cleveland Browns

Sunday, October 5 – 12:30am AEST – Tottenham Hotspur Stadium, London, UK

London games often come down to discipline and ball security, and that gives Minnesota the edge. The Browns are still searching for offensive rhythm, and their quarterback protection has been shaky. The Vikings should generate enough defensive stops to back their offence and cover the line comfortably.

Baltimore Ravens v Houston Texans

Monday, October 6 – 4:00am AEST – M&T Bank Stadium, Baltimore, MD

Injuries have left Baltimore vulnerable, but this is still a bounce-back spot. The Texans haven’t shown enough cutting edge in attack, often settling for field goals instead of touchdowns. Even with Lamar Jackson in doubt, the Ravens’ home ground advantage and defensive grit make them a solid play.

New York Giants v New Orleans Saints

Monday, October 6 – 4:00am AEST – Caesars Superdome, New Orleans, LA

The Giants are playing with more confidence under Jaxson Dart, while the Saints are winless and under pressure. New Orleans’ offensive line has struggled, but Chris Olave continues to be the bright spark. With his target share rising, he looks the most likely Saint to cross for a touchdown at home.

Carolina Panthers v Miami Dolphins

Monday, October 6 – 4:00am AEST – Bank of America Stadium, Charlotte, NC

Miami snapped their losing run last week, but they now need to find ways to score without Tyreek Hill. That should mean more work for Jaylen Waddle, who has the pace and timing to trouble the Panthers’ defence. In a game that could swing either way, Waddle offers standout value as a touchdown pick.

Las Vegas Raiders v Indianapolis Colts

Monday, October 6 – 4:00am AEST – Lucas Oil Stadium, Indianapolis, IN

Both sides can score quickly, and turnovers could spark short fields at either end. Jonathan Taylor remains in red-hot form, while the Raiders’ attack has clicked in patches. With both defences prone to lapses, this shapes as a high-scoring contest.

Philadelphia Eagles v Denver Broncos

Monday, October 6 – 4:00am AEST – Lincoln Financial Field, Philadelphia, PA

The Eagles keep finding a way, even when not playing their best football. Denver’s defence will challenge them, but travelling east on a short turnaround is far from ideal. Expect a tight contest where Philly’s class late should carry them home inside two scores.

New York Jets v Dallas Cowboys

Monday, October 6 – 4:00am AEST – MetLife Stadium, East Rutherford, NJ

Dallas showed their offensive punch in the high-scoring draw with Green Bay and now face a Jets outfit that struggles to keep pace. New York’s defence is leaky, and their attack has been inconsistent at best. The Cowboys should have too much firepower and cover the narrow line.

Arizona Cardinals v Tennessee Titans

Monday, October 6 – 7:05am AEST – State Farm Stadium, Glendale, AZ

The Cardinals have leaned heavily on Trey McBride in the red zone, and his chemistry with Kyler Murray keeps growing. Tennessee’s defence has been exposed by tight ends, and this shapes as another chance for McBride to strike. With Arizona expected to dominate possession, he’s strong value to score.

Seattle Seahawks v Tampa Bay Buccaneers

Monday, October 6 – 7:05am AEST – Lumen Field, Seattle, WA

Seattle’s pass defence is among the league’s best, but Tampa Bay still have emerging playmakers. Rookie Emeka Egbuka has been used in key scoring situations and continues to build confidence. At generous odds, he looks a value anytime touchdown option.

Los Angeles Chargers v Washington Commanders

Monday, October 6 – 7:25am AEST – SoFi Stadium, Inglewood, CA

Injuries have hurt the Chargers’ offensive line, but Justin Herbert still has the weapons to get it done at home. Washington are unpredictable and often leave themselves chasing games late. If LA take control early, they should see out a cover at home.

Cincinnati Bengals v Detroit Lions

Monday, October 6 – 7:25am AEST – Paycor Stadium, Cincinnati, OH

The Lions are rolling and look one of the league’s most complete sides right now. Cincinnati are struggling for answers and will be under pressure from the start. Detroit’s balance on both sides of the ball makes a two-touchdown margin very achievable.

Buffalo Bills v New England Patriots

Monday, October 6 – 11:20am AEST – Highmark Stadium, Orchard Park, NY

Josh Allen has enjoyed plenty of success against the Patriots, and this shapes as another chance to dominate. New England’s defence is vulnerable to mobile quarterbacks, especially in broken plays. If Allen is forced to take off, he should clear the rushing line with ease.

Jacksonville Jaguars v Kansas City Chiefs

Tuesday, October 7 – 11:15am AEST – EverBank Stadium, Jacksonville, FL

Jacksonville are 3–1 and brimming with belief thanks to Travis Etienne’s consistency on the ground. Kansas City are still searching for rhythm outside of Mahomes, leaving them vulnerable on the road. At home, the Jags are a live chance and present serious value to close the round.

NFL Week 5 multi of the week

All 14 legs combined

• Under 45.5 (49ers v Rams)
• Vikings -3.5
• Ravens to win
• Chris Olave anytime TD
• Jaylen Waddle anytime TD
• Over 48.5 (Raiders v Colts)
• Eagles by 1–13 pts
• Cowboys -2.5
• Trey McBride anytime TD
• Emeka Egbuka anytime TD
• Chargers -2.5
• Lions 14+
• Josh Allen 40+ rushing yards
• Jaguars to win

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