NFL Week 4 betting tips, predictions & multi picks

The 2025 NFL season hits Week 4 with clearer reads on every team — and a quirky schedule that includes an overseas showdown in Dublin.

From a Thursday divisional clash in the desert to a Monday night double-header, here are our top betting plays for every matchup, with prices from the top online bookmakers.

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  Fast Payouts

Seattle Seahawks v Arizona Cardinals

Friday, September 26 – 10:15am AEST – State Farm Stadium, Glendale, AZ

Seattle’s attack has clicked over the past fortnight, while Arizona games have lifted with both red-zone defences under heat. Indoors, sustained drives should turn into points more often. The total still looks a touch shy for this rivalry.

Minnesota Vikings v Pittsburgh Steelers

Sunday, September 28 – 11:30pm AEST – Croke Park, Dublin, Ireland

Both sides have lived on fine margins, but the Steelers have closed better and bring a defence that travels well. On neutral turf with little between them, Pittsburgh’s consistency makes the outsider odds appealing.

Washington Commanders v Atlanta Falcons

Monday, September 29 – 3am AEST – Mercedes-Benz Stadium, Atlanta, GA

Washington have cleaned up the errors — fewer giveaways, fewer costly flags — and it shows late in games. Atlanta move the ball in bursts but stall inside the 20. If the Commanders protect possession, a road steal is on the cards.

New Orleans Saints v Buffalo Bills

Monday, September 29 – 3am AEST – Highmark Stadium, Orchard Park, NY

Buffalo have been brutal at home: quick runs of points, short fields from teams, and a defence that squeezes when you chase. The Saints are looser than they were, but tempo and physicality still tilt to the Bills. If they surge around halftime again, points should pile up.

Tennessee Titans v Houston Texans

Monday, September 29 – 3am AEST – NRG Stadium, Houston, TX

Houston keep things measured, own the middle of the field, and trust their red-zone defence. Tennessee’s drives too often end in three points, not seven. In a low-variance script, the Texans’ habit of closing one-score games at home gives them the edge.

Los Angeles Chargers v New York Giants

Monday, September 29 – 3am AEST – MetLife Stadium, East Rutherford, NJ

The Chargers have been better at both ends of the game, jumping ahead early and letting the rush disrupt rhythm. New York’s third downs and red-zone returns remain poor, which blunts backdoor chances. If LA control field position again, this line is well within reach.

Philadelphia Eagles v Tampa Bay Buccaneers

Monday, September 29 – 3am AEST – Raymond James Stadium, Tampa, FL

Philly keep threading the needle in close ones, finishing with superior late-game execution and line control. Tampa are competitive, but sustaining long marches against this front is tough. With the Eagles’ poise, a short road spread is fine.

Carolina Panthers v New England Patriots

Monday, September 29 – 3am AEST – Gillette Stadium, Foxborough, MA

Carolina lack week-to-week consistency and don’t mount enough scoring pressure on the road. New England’s home discipline should tell, particularly in a lower total where field position matters. The hosts look set to land in the narrow margin band.

Cleveland Browns v Detroit Lions

Monday, September 29 – 3am AEST – Ford Field, Detroit, MI

Detroit are stacking quality at home and come in hot after upsetting the Ravens. The Browns’ road form is patchy, and finishing drives against this front line is an issue. In the dome, the Lions’ tempo can snowball; if they grab an early lead, it can blow out late.

Indianapolis Colts v Los Angeles Rams

Monday, September 29 – 6:05am AEST – SoFi Stadium, Inglewood, CA

The Rams are the tidier side, taking points when offered and avoiding freebies. Indy show bursts but still cough up errors in big moments. LA’s red-zone discipline and end-of-half control provide the home edge.

Jacksonville Jaguars v San Francisco 49ers

Monday, September 29 – 6:05am AEST – Levi’s Stadium, Santa Clara, CA

San Francisco’s defence is a weekly exam, but Jacksonville’s balanced early-down approach limits negative plays and keeps a late cover route open. With steady specials and a reliable two-minute drill, the Jags can hang within a field goal.

Chicago Bears v Las Vegas Raiders

Monday, September 29 – 6:25am AEST – Allegiant Stadium, Las Vegas, NV

Chicago have improved their drive sustain and trimmed empty possessions. Vegas struggle to find rhythm, especially from behind. The Bears’ balanced approach travels well, and if they protect the ball, they should be good enough to get it done.

Baltimore Ravens v Kansas City Chiefs

Monday, September 29 – 6:25am AEST – GEHA Field at Arrowhead Stadium, Kansas City, MO

Neither side has peaked yet, but Baltimore’s dip — off a poor loss to Detroit — is notable. Arrowhead is a tough reset venue, and Kansas City usually execute better in late moments at home. Keeping it inside a field goal is a live outcome.

Green Bay Packers v Dallas Cowboys

Monday, September 29 – 10:20am AEST – AT&T Stadium, Arlington, TX

Dallas limp in after a heavy defeat and injuries on both sides of the ball, with CeeDee Lamb (ankle) out for several weeks and DaRon Bland battling a foot issue. Green Bay can control early downs, force chase mode, and stretch late. A big win is well within reach for the Packers.

New York Jets v Miami Dolphins

Tuesday, September 30 – 9:15am AEST – Hard Rock Stadium, Miami Gardens, FL

Miami are still chasing their first win, but a spirited effort against Buffalo hinted at progress. Back at home, this is a chance to turn improved structure into a result against a Jets outfit that’s been hot-and-cold. Keep turnovers down and the Dolphins should control the key moments.

Cincinnati Bengals v Denver Broncos

Tuesday, September 30 – 10:15am AEST – Empower Field at Mile High, Denver, CO

Without Joe Burrow last week, Cincinnati’s offence lost bite and Ja’Marr Chase couldn’t lift the offence on his own. Denver’s defence tightens at altitude, and visiting attacks often fade late. If the Broncos dictate tempo again, a touchdown-plus margin is there for the taking.

NFL Week 4 multi of the week

All 16 legs combined

• Over 42.5 (Seahawks v Cardinals)
• Steelers to win
• Commanders to win
• Over 47.5 (Saints v Bills)
• Texans by 1–13 pts
• Chargers -6.5
• Eagles -2.5
• Patriots by 1–13 pts
• Lions 14+
• Rams to win
• Jaguars +3.5
• Bears to win
• Chiefs +3.5
• Packers by 14+ pts
• Dolphins to win
• Broncos -7.5

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