NFL Week 1 betting tips, multi picks & predictions

The 2025 NFL season kicks off with blockbuster matchups across the board — from fierce divisional rivalries to debut games for big-name rookies.

Week 1 delivers it all: Super Bowl hopefuls, fresh quarterback storylines, and even the league’s first-ever match in Brazil. It’s a dream start for punters chasing early-season value.

Here’s your full NFL Week 1 betting preview, packed with expert predictions, betting tips, and odds with the top online bookmakers.

Philadelphia Eagles v Dallas Cowboys

Friday, September 5 – 10:20am AEST – Lincoln Financial Field, Philadelphia

The Eagles begin their season at home against a Cowboys side missing key stars. With Saquon Barkley added to Jalen Hurts in one of the league’s deepest offences, Philadelphia should dominate both lines. Dallas are undermanned and unlikely to cope with the Eagles’ pace and power. Expect a strong statement win from the hosts.

Kansas City Chiefs v Los Angeles Chargers

Saturday, September 6 – 10am AEST – Arena Corinthians, São Paulo

The Chiefs and Chargers face off in Brazil to open their campaigns. Kansas City swept Los Angeles last year and enter with a stronger balance on both sides of the ball. The Chargers’ offensive line remains a major concern and could struggle to protect Justin Herbert, so back the Chiefs for a comfortable win.

Washington Commanders v New York Giants

Monday, September 8 – 3am AEST – FedEx Field, Maryland

Jayden Daniels makes his debut for Washington against a fierce Giants pass rush. Both sides bring plenty of defensive pressure but carry major doubts in attack. This game has grind written all over it, and the total looks too high for two unsettled offences.

Jacksonville Jaguars v Carolina Panthers

Monday, September 8 – 3am AEST – EverBank Stadium, Jacksonville

Both Jacksonville and Carolina struggled defensively last season, finishing near the bottom of the NFL in efficiency. Jags quarterback Trevor Lawrence should find plenty of space to attack the Panthers’ secondary, while Bryce Young will need to take risks just to keep it close. With weak defences on both sides, this should clear the points line.

New York Jets v Pittsburgh Steelers

Monday, September 8 – 3am AEST – MetLife Stadium, New York

Aaron Rodgers returns for the Jets but faces a Steelers defence that rarely gives up easy scores. Both teams are inconsistent in attack and could start slowly. With conservative playbooks and field position dictating terms, this game looks like a defensive battle. The under shapes as the best value.

New England Patriots v Las Vegas Raiders

Monday, September 8 – 3am AEST – Gillette Stadium, Foxborough

The Patriots are rebuilding with young talent and face a Raiders side revitalised under Pete Carroll. Las Vegas should play at a higher tempo with Geno Smith steering the attack, while New England’s defence might take time to settle against this style. The over looks appealing.

New Orleans Saints v Arizona Cardinals

Monday, September 8 – 3am AEST – Caesars Superdome, New Orleans

Cardinals quarterback Kyler Murray is fully fit and has rookie Marvin Harrison Jr. to target in key moments. The Saints’ defence is ageing and may struggle with Arizona’s speed across the field. Harrison has been heavily involved in red-zone sets during the preseason, and he offers excellent value to score on debut.

Cleveland Browns v Cincinnati Bengals

Monday, September 8 – 3am AEST – Cleveland Browns Stadium, Cleveland

Cincinnati boast one of the league’s most talented rosters and will look to start fast. Joe Burrow has protection and an arsenal of weapons to break open this divisional clash. As Cleveland’s offence still carries doubts, the Bengals should cover on the road.

Indianapolis Colts v Miami Dolphins

Monday, September 8 – 3am AEST – Lucas Oil Stadium, Indianapolis

The Colts will try to grind out a result with their running game, but the Dolphins remain more dynamic. Miami’s offence is built on pace and timing, and Tua Tagovailoa should get the ball out quickly. If they strike early, Indianapolis may be left chasing. The visitors look a class above.

Atlanta Falcons v Tampa Bay Buccaneers

Monday, September 8 – 3am AEST – Mercedes-Benz Stadium, Atlanta

Atlanta will try to dominate possession with their run-heavy approach, but Tampa Bay’s aerial attack is dangerous. Mike Evans has an excellent record in this divisional matchup and is Baker Mayfield’s go-to option in the red zone. If the Buccaneers can protect their quarterback, Evans should capitalise.

Denver Broncos v Tennessee Titans

Monday, September 8 – 6:05am AEST – Empower Field at Mile High, Denver

The Broncos’ defence thrives at home, and the altitude will not help Tennessee’s rookie quarterback, Cam Ward. Denver should generate pressure throughout and dominate field position. Sean Payton’s structured offence should provide enough support for Russell Wilson to guide the home side to a comfortable win.

Seattle Seahawks v San Francisco 49ers

Monday, September 8 – 6:05am AEST – Lumen Field, Seattle

Seattle are always tough at home and boast a defence on the rise. The 49ers come in with injury concerns and Brock Purdy still regaining sharpness. The Seahawks’ pressure game could force mistakes, so there is genuine upset potential in this divisional clash.

Green Bay Packers v Detroit Lions

Monday, September 8 – 6:25am AEST – Lambeau Field, Green Bay

This NFC North rivalry looks set for fireworks. Both quarterbacks are in form and supported by deep offensive groups. Defence may take a back seat in a high-tempo contest, so take the over.

Los Angeles Rams v Houston Texans

Monday, September 8 – 6:25am AEST – SoFi Stadium, Los Angeles

The Rams have issues protecting Matthew Stafford but still carry big-game experience. Houston’s defence is improving quickly, but their offence is still developing. Cooper Kupp’s return should give Los Angeles the spark they need to get the job done.

Buffalo Bills v Baltimore Ravens

Monday, September 8 – 10:20am AEST – Highmark Stadium, Buffalo

The Bills are nearly unbeatable at home in primetime, with Josh Allen thriving in these situations. Baltimore have added more weapons but will find Buffalo’s defence difficult to break. Expect a playoff-style clash with momentum swings on both sides. Buffalo’s home edge should see them home late.

Chicago Bears v Minnesota Vikings

Tuesday, September 9 – 10:15am AEST – Soldier Field, Chicago

The Caleb Williams era begins for the Bears at Soldier Field against their division rivals. Chicago finally have the firepower with DJ Moore, Keenan Allen and Rome Odunze stretching defences. The Vikings are transitioning after Kirk Cousins and have major holes in their secondary. The Bears can start their season with a statement win.

NFL Week 1 multi of the week

All 16 legs combined

• Eagles -8.5
• Chiefs -3.5
• Under 45.5 (Commanders v Giants)
• Over 46.5 (Jaguars v Panthers)
• Under 38.5 (Jets v Steelers)
• Over 43.5 (Patriots v Raiders)
• Marvin Harrison Jr. anytime TD
• Bengals -4.5
• Dolphins to win
• Mike Evans anytime TD
• Broncos -7.5
• Seahawks to win
• Over 47.5 (Packers v Lions)
• Rams to win
• Bills to win
• Bears to win

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