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Giants @ 49ers NFL Thursday betting tips – September 21, 2023

NY Giants @ San Francisco 49ers betting tips

The NFL’s Thursday Night Football is back, featuring a Week 3 clash between the undefeated San Francisco 49ers and the New York Giants, who are looking to bounce back from a mixed start. While both teams made the playoffs last year, the 49ers enter this matchup as heavy favourites. Here are our free betting picks for this September 21 showdown, with odds from the top NFL bookmakers.


Spread pick: New York Giants +10.5

The Giants might not be the favorites in this matchup, but we believe they have what it takes to keep it competitive. Despite the Niners’ strong start and the Giants’ early stumbles, New York hasn’t hit their full potential yet. Even without their star running back Saquon Barkley, the Giants boast enough talent to stay in the game. Thursday night games often come with their fair share of sloppiness, which could level the playing field. Taking the underdogs with a hefty spread seems like a promising play.

New York Giants +10.5

-110
@
Marantelli Bet

Anytime touchdown pick: Matt Breida (Giants)

With Saquon Barkley sidelined due to injury, Matt Breida steps up as the Giants’ primary running back. While the 49ers boast a formidable defense, the odds on Breida finding the end zone at any point in the game are too enticing to ignore. The Giants may face challenges on the ground, but Breida’s versatility as a pass-catcher gives him multiple avenues to breach the San Francisco defense.

Matt Breida anytime touchdown

+350
@
Marantelli Bet

Anytime touchdown pick: George Kittle (49ers)

George Kittle stands as one of the league’s premier tight ends, and while he’s yet to find the end zone this season, he notched an impressive 11 touchdowns last year. Kittle’s blend of size and speed presents a formidable challenge for the Giants’ defense. Although New York has shown averageness against opposing tight ends in the early weeks, Kittle operates on a different plane. We fancy him to find paydirt in this Thursday Night face-off.

George Kittle anytime touchdown

+350
@
Marantelli Bet

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